Isotretinoin - Side Effects That Need Medical Monitoring By Your Physician

Certain Isotretinoin (Accutane®) side effects will not be as apparent to you and will need to be monitored by your doctor during your acne treatment. These include effects on your bones, lipids, liver and pregnancy status.

Pregnancy:

• This drug is teratogenic and causes fetal abnormalities
• YOU CANNOT RISK BECOMING PREGNANT. YOU MUST AVOID PREGNANCY 1 MONTH BEFORE, DURING, AND 1 MONTH AFTER USE OF THIS DRUG
• Pregnancy prevention programs are offered to ensure that you avoid getting pregnant
• Talk to your doctor about this

Depression:

• There are reports that Isotretinion may cause depression and mood changes.
• It is wise to look out for suspicious changes in mood although a direct causal relationship has not been established.
• Clinical experience suggests that some patients become moody on this drug.
• An increase risks of suicide has received much press but has not been substantiated.
• It is prudent to be aware and closely observe patients that might be at risk.

Bones:

• Hyperostosis, osteophytes (bony spurs) may develop, but are usually of little consequence
• There is a possible risk that your bones will become thinner (osteoporosis)
• (however, more work needs to be done, as studies have been inconclusive)
• Premature closure of bony epiphyses can occur in children, which may reduce long bone growth

Lipids:

• Cholesterol/ triglyceride levels may increase, this must be followed by your doctor
• You may experience a short-term increase in cholesterol, though this is not thought to be very significant
• Pancreatitis is a risk if your triglycerides rise quickly and the level becomes high, this is very rare, however

Liver:

• May be mildly irritating to your liver

Blood tests occasionally show changes but they are usually of little consequence. It is rare to have to discontinue Accutane® because of liver abnormalities. Drug induced hepatitis has been reported.

Neurologic:

• A pseudotumor in the cerebrum can occur, which can cause increased brain fluid pressure, headaches, vomiting, and visual disturbances
• Depression and suicidal thoughts have been reported in some patients,
• nobody knows for sure, though, if it was isotretinoin or other factors that caused these feelings
• You may experience headaches

Muscloskeletal:

• There is a risk of inflammation around joints, and tendonitis
• Aches and pains around joints, and lower back pain are common

These symptoms do not produce permanent damage in the joints and often taking anti-inflammatory painkillers can give you relief.

Blood:

Your ability to produce white blood cells may be diminished (called leukopenia). However, this is rare.

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